The regulation and cellular functions of phosphatidylcholine hydrolysis.
نویسندگان
چکیده
Ca2+-mobilizing agonists, including hormones, neurotransmitters and growth factors, cause profound changes in cellular lipid metabolism. These changes are initiated by receptormediated activation of various phospholipases including phospholipase A2, phospholipase C and phospholipase D. Phospholipase A2 hydrolyses several phospholipids including phosphatidylinositol, phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) to liberate arachidonic acid and the respective lysophospholipids. Arachidonic acid is converted via the cyclo-oxygenase and lipoxygenase pathways to eicosanoids, including prostaglandins, thromboxanes, prostacyclins, leukotrienes and lipoxins [1]. Certain lysophospholipids such as ether-linked lysophosphatidylcholine
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ورودعنوان ژورنال:
- The Biochemical journal
دوره 269 2 شماره
صفحات -
تاریخ انتشار 1990